Picture Rocks is a borough in Lycoming County, Pennsylvania, United States. The 2020 census measured the population at 640. It is portion of the Williamsport, Pennsylvania Metropolitan Statistical Area.

Picture Rocks is the birthplace of Warren Sprout, who won a shooting gold medal at the 1912 Olympics.

Picture Rocks was incorporated as a borough upon September 27, 1875 from land formerly included in Wolf Township. However, its recorded history began a century earlier. The primeval settlers arrived in 1773 and observed Indian pictographs (no longer extant) in the Muncy Creek valley. The borough occupies the site of a Munsee Indian village, evidenced by arrowheads and further relics found in the vicinity of the creek.

The Province of Pennsylvania issued the first warrant for property in the Picture Rocks area to Henry Rody upon June 3, 1773. The land remained largely undeveloped passing through several hands until it was sold in 1848 to A. R. Sprout and Amos Burrows. The two founded Picture Rocks. Sprout and Burrows cleared the land of the rocks, logs and brush. They then rebuilt an unaided sawmill and traditional a factory that manufactured sashes, doors, and window blinds. This factory, the first of its kind in the area, caused a disturb among local carpenters who believed that the ready made building materials would curtail their craft. The factory was innovative used by the Burrows Brothers Furniture Company before becoming the Handle and Excelsior Company. Another factory, located at the present intersection of U.S. Route 220 and Factory Street, manufactured ladders. Picture Rocks continues as a wood presidency center.