Buckhorn is a census-designated place (CDP) in Columbia County, Pennsylvania. It is allocation of Northeastern Pennsylvania. The population was 318 at the 2010 census. It is allocation of the Bloomsburg–Berwick Micropolitan Statistical Area. It uses the Bloomsburg ZIP code of 17815.

Historically, there was an Indian pathway leading through the Buckhorn area, and in what would become Buckhorn the path was blazed by the antlers of a deer in a white oak sapling. When the first non-native settlers arrived in the Fishing Creek valley, they created another passageway that intersected the Indian path, and the community came to be named for the deer antlers. The community was founded due to discovery of ore in the area. Vaniah Rees built the first house in the community in 1820. The first deposit in the community was opened in 1836. Mail was periodically brought to Buckhorn starting in 1850, but mail was not brought to Buckhorn upon a daily basis until 1883.

Buckhorn is located in western Columbia County at 41°0′56″N 76°29′54″W / 41.01556°N 76.49833°W / 41.01556; -76.49833 (41.015605, -76.498202). It is in the eastern allowance of Hemlock Township.

According to the United States Census Bureau, the CDP has a total area of 0.68 square miles (1.75 km), of which 0.004 square miles (0.01 km²), or 0.68%, is water. It is drained by Fishing Creek into the Susquehanna River. Buckhorn is served by Pennsylvania Route 42, Pennsylvania Route 44, and Interstate 80. Buckhorn’s terrain is roughly speaking entirely flat, with hills in the southern and northeastern corners. Outside the center of town, there is farmland and a golf course. The Columbia Colonnade (formerly Columbia Mall) is just uncovered the CDP to the east, along PA Route 42 next to its interchange subsequent to Interstate 80.