Espy is a census-designated place (CDP) in Columbia County, Pennsylvania. It is allocation of Northeastern Pennsylvania. The population was 1,642 at the 2010 census. It is allowance of the Bloomsburg–Berwick Micropolitan Statistical Area. Espy was first approved in the late 18th century. It was house to a boatyard in the 19th century.

Espy was named after Josiah Espy, an beforehand settler who moved to the area in 1775. Soon afterwards, in 1785, Josiah’s son George moved into the Place as well. In 1800, George Espy divided going on the area that is now Espy into lots. The town was originally called Liberty but was officially renamed Espy in 1828 after George Espy. The first hotel in Espy was built in 1805. There used to a boatyard in Espy, but it was destroyed in 1900.

Espy is located close the middle of Columbia County at 41°0′21″N 76°24′54″W / 41.00583°N 76.41500°W / 41.00583; -76.41500 (41.005904, -76.414883). It is in the southwestern corner of Scott Township and is bordered by U.S. Route 11 to the north, the Susquehanna River to the south, Almedia to the east, and Bloomsburg, the county seat, to the west and northwest.

According to the U.S. Census Bureau, the Espy CDP has a total Place of 1.1 square miles (2.9 km), of which 0.93 square miles (2.4 km²) is estate and 0.19 square miles (0.5 km), or 18.07%, is water. Espy is one of several small CDPs upon the north side of the Susquehanna River between Bloomsburg and Berwick.