Lewisburg is a borough in Union County, Pennsylvania, United States, 30 miles (48 km) south by southeast of Williamsport and 60 miles (97 km) north of Harrisburg. In the past, it was the commercial middle for a fruitful grain and general cultivation region. The population was 5,158 as of the 2020 census. It is the county chair of Union County. Located in central Pennsylvania’s Susquehanna River Valley, on the West Branch Susquehanna River, Lewisburg is northwest of Sunbury. It is home to Bucknell University and is near the Lewisburg Federal Penitentiary. Its 19th-century downtown is upon the National Register of Historic Places. Lewisburg is the principal city of the Lewisburg, PA Micropolitan Statistical Area, and is also allocation of the larger Bloomsburg-Berwick-Sunbury, PA Combined Statistical Area.

Lewisburg was founded in 1785 by Ludwig Derr. A settler of the area (since as beforehand as 1763–1769), Derr had purchased several tracts of land from the William Penn associates and other adjoining land owners, the largest of which was known as “The Prescott”. Having been on the estate for such a long time, Derr had befriended the local Native Americans of the area. His membership with these native peoples was so well founded that, even as many of the additional local settlers’ homesteads were routinely sacked by Native Americans, Derr’s lands remained clear from attacks. Subsequently, in 1784, he worked subsequently Samuel Weiser to lay out his combined house tracts, and Make Derrstown. The pronounce was well along changed to Lewisburgh once Snyder County was created from Union County in 1855 (according to a local Keystone marker sign), but was known on original plans and happenings as Lewisburg since that time (also see note below).

Much has been considered regarding ‘how’ the name untouched from Derrstown to Lewisburg. The most likely truth is that Derr’s first name “Ludwig” translated into English as “Louis” but, being of German descent, it was spelled “Lewis”. Later, after Derr’s death, the standard Germanic “burgh” was appended to his first post to Make Lewisburgh.^{[citation needed]}

Note: U.S. Postal Service history contradict this story. The herald office was named Lewisburgh when it was normal in 1796; in 1893, the post was abbreviated to Lewisburg.