Sperryville is a census-designated place (CDP) located in the western section of Rappahannock County, Virginia, United States, near Shenandoah National Park. It consists of a village next two main streets along the two branches of the Thornton River, together in the same way as surrounding pasture- and farmland. The population as of the 2010 Census was 342.

The land on which Sperryville is located is share of 3,000 acres granted by King George II of Great Britain to Francis Thornton in 1731.  This land was regranted to Thornton in 1751 by Thomas Fairfax, 6th Lord Fairfax of Cameron, owner of the Northern Neck Proprietary, after Fairfax won his raid to prevent the king from granting house in the Proprietary. Part of this home was familial by a descendant, also named Francis Thornton, in 1817. He was a soldier in the War of 1812, became a Presbyterian minister, and was sent from his home in Fredericksburg, Virginia, to organize a Presbyterian church in what was after that western Culpeper County. In 1820 he began selling little lots of home along the main road (currently Main Street, VA Route 1001). The first success was for a ½-acre lot “in a Tiny town laid off by me, the said Francis Thornton Jr., and surveyed by Johnston Menefee … the village is in a flat neighboring the lands of John Menefee amongst the Pass Mill (today’s Fletcher’s Mill) and Thornton’s Gap.” The village of Sperryville is named upon an 1821 map of Culpeper County created by John Wood.

On one of the lots, John Hopkins established an ‘ordinary’ that well along became a boarding home for immigrant Irish laborers. On other lot was a tavern and stage coach office to serve people traveling from Culpeper Court House to New Market, Virginia. On further lots were a cobbler’s shop, stores, and individual homes. In the to the fore 1800s John Kiger built Conestoga wagons in the area. The say office was standard in the village in 1840. In the 1850s several turnpikes were build up that accessed Sperryville: Thornton’s Gap from Culpeper to Sperryville, Newmarket & Sperryville, and Sperryville-Rappahannock from Sperryville east to the Rappahannock River. A tannery and worker’s homes were build up in the late 1860s by the Smoot family.  Four churches were conventional in the Place by 1880, as with ease as a woolen mill, seven distillers, two hotels, four general stores, and one saloon.  There were after that ten corn and flour mills nearby. An apple processing capability was built in 1918 to help the many local apple orchardists. Sperryville tall school was build up adjacent to the town. In the 1930s, a Civilian Conservation Corps camp located at Beech Spring west of the village provided farmers similar to a reachable market for produce, meat, milk, and eggs to feed the corpsmen housed there.  The Sperryville apple packing and juice forest was created on the site of the former Smoot tannery.

The Sperryville Historic District was listed upon the Virginia Landmarks Registry in 1982 and on the National Register of Historic Places in 1983.