Montoursville is a borough in Lycoming County, Pennsylvania. The 2020 census reported its population as 4,745. It forms ration of the Williamsport, Pennsylvania Metropolitan Statistical Area. The Williamsport Regional Airport is in Montoursville.

Developed on the east bank of Loyalsock Creek close the former native village of Otstonwakin, the borough is named for Andrew Montour, the French/Native American and son of Madame Montour, a Native American interpreter and negotiator who served the British colonial direction in New York and Pennsylvania during the in advance eighteenth century. She led the original village. Her son along with became influential as an interpreter and negotiator, serving colonial governments in Pennsylvania and Virginia, including during the French and Indian War.

Otstawonkin was a indigenous village located at the mouth of Loyalsock Creek on the West Branch Susquehanna River. The Great Shamokin Path ran along the west bank of the river, where late 20th century archeology has shown the village was mostly located. During the 1730s and 1740s, it became an important stopping point for Moravian missionaries who preached in frontier Pennsylvania. For example, Count Zinzendorf, a missionary guided by Conrad Weiser in the same way as the admission of Oneida chief Shikellamy, came to Otstonwakin in 1742.

Madame Montour is believed to have been of Algonkin-French ancestry, born in Quebec. In one account, she told a colonist in the 1740s that she had been taken captive in an Iroquois combat and adopted into an Iroquois family. (Her firm name may have been Catherine, Elisabeth/Isabelle, or Madeleine.) Speaking French and English, as skillfully as Algonquian and Iroquoian languages, she became severely influential in New York, and acted as Governor Robert Hunter’s personal interpreter.