Grand Junction is a city amongst the be stuffy to of Hardeman and Fayette County, Tennessee, United States. The population was 325 at the 2010 census, and was estimated to be 303 in 2015.

It has been called the “Bird Dog Capital of the World” and serves as the location of the National Bird Dog Museum.

Grand Junction was founded in 1858. It was named after the “Grand Junction” of the Memphis and Charleston Railroad and the Mississippi Central Railroad. The town was a railroad town, with its own newspaper, two saloons, three hotels, a livery stable, and supplementary businesses. During the Civil War, the Union Army held the city for nearly three years. Also during the Civil War General U.S. Grant normal a “Contraband Camp” of thousands of former enslaved people, providing shelter, education etc. prior to the Emancipation Proclamation. (Ron Chernow, p 230) In 1878 a orange fever epidemic struck the town and killed more than half of the 150 residents. The town was incorporated in 1901.

Grand Junction is located in southwestern Hardeman County at 35°2′53″N 89°11′25″W / 35.04806°N 89.19028°W / 35.04806; -89.19028 (35.048023, -89.190177). A little portion of the town extends west into Fayette County. Tennessee State Route 57 runs through the city, leading east 17 miles (27 km) to Middleton and west 3.5 miles (5.6 km) to La Grange. Collierville, on the outskirts of the Memphis suburbs, is 28 miles (45 km) to the west upon TN 57. Tennessee State Route 18 runs with the western edge of Grand Junction, leading northeast 19 miles (31 km) to Bolivar and southwest 4 miles (6.4 km) to the Mississippi border, beyond which Mississippi Highway 7 continues southwest 20 miles (32 km) to Holly Springs. Tennessee State Route 368 is a local highway that runs through downtown Grand Junction.