Wedgefield is an unincorporated community in the High Hills of Santee Place in western Sumter County, South Carolina, United States. Wedgefield is with a Census Designated Place (CDP). Wedgefield was hence named because its location was likened to a “wedge” into the High Hills of Santee. In the 18th and 19th centuries it was the location of many plantations, notably those of the Singleton family, which produced First Lady of the United States, Angelica Singleton Van Buren. Today the plantations are like except for their cemeteries and Wedgefield is today noted as the location of a give leave to enter park, a let in forest and extra recreational places. When the railroad came through in the 19th century, the commercial center of Wedgefield developed at the intersection of the railroad, Kings Highway (South Carolina Highway 261) and Wedgefield Road (South Carolina Highway 763). It has its own state office considering the Zip Code of 29168.

Wedgefield had a population of 3,376 in 2000 on a Zip Code-based estimate. Housing units were 1,343. Land Place is 71.9 square miles (186 km) while water area is 0.33 square miles.

South Carolina Highway 261, Kings Highway, is the main north–south road in Wedgefield. It runs north to Stateburg and south to Pinewood. Wedgefield Road (South Carolina Highway 763) begins in Wedgefield and runs east to Sumter.
CSX Transportation, formerly the Seaboard Coast Line Railroad runs into Wedgefield from Sumter just north of Wedgefield Road and continues to the west. There is no passenger bolster to Wedgefield.

Cemeteries in the Wedgefield Place include: