Wattsville is an unincorporated community in Laurens County, South Carolina, United States. The town broadcast is derived from Watts Mill, a textile mill in the middle of town. The Place is listed as the Wattsville census-designated place (CDP) for statistical purposes. The population of the CDP was 1,635 at the 2010 census. It is share of the Greenville–Mauldin–Easley Metropolitan Statistical Area.

Wattsville is located in central Laurens County at 34°30′55″N 81°59′39″W / 34.515305°N 81.994227°W / 34.515305; -81.994227 and is bordered to the southwest by the city of Laurens, the county seat. U.S. Route 221 passes through the center of Wattsville, leading north 34 miles (55 km) to Spartanburg and south through Laurens 27 miles (43 km) to Greenwood. South Carolina Highway 49 leaves US 221 in Wattsville, leading northeast 29 miles (47 km) to Union. Interstate 385 passes 2 miles (3 km) north of Wattsville, with permission from both US-221 and SC-49.

According to the United States Census Bureau, the CDP has a total area of 2.3 square miles (5.9 km), all land. The middle of the community occupies a ridge surrounded by south-flowing streams that gain to the Little River, a southeast-flowing tributary of the Saluda River.

As of the census of 2010, there were 1,635 people, 564 households, and 356 families residing in the CDP. The population density was 646.8 people per square mile (249.4/km²). There were 629 housing units at an average density of 275.1/sq mi (106.1/km). The racial makeup of the CDP was 68.29% White, 16.23% African American, 2.77% Native American, 0.20% Pacific Islander, 9.33% from supplementary races, and 3.18% from two or more races. Hispanic or Latino of any race were 16.36% of the population.