Pendleton is a town in Anderson County, South Carolina, United States. The population was 3,489 at the 2020 census. It is a sister city of Stornoway in the Outer Hebrides of Scotland.

The Pendleton Historic District, consisting of the town and its short surroundings, was further to the National Register of Historic Places in 1970. Particularly notable historic buildings on the Pendleton town square tally Farmer’s Hall and Hunter’s Store, which is currently the headquarters of the Pendleton District Historical, Recreational and Tourism Commission. Near Pendleton are the historic plantation homes Ashtabula and Woodburn.

For centuries, the house that is now Pendleton was the territory of the Cherokee nation. After England claimed South Carolina as a colony, the Cherokee traded behind the British. After the Cherokee loose the encounter of 1759–60 next to the British, the British dominated trade in the region and began to be of the same opinion more of the home with large farms. Andrew Pickens, who was a general in the Revolutionary War moved to the area and commissioned the District of Pendleton in 1790. During the first half of the 1800s, wealthy families built homes in Pendleton. These homes were built as a summer vacation spot for the low-country plantation owners. Charles Cotesworth Pinckney (1789–1865) built Woodburn Plantation in 1830. Later, the Adger family, a wealthy family from Charleston, expanded the plantation to exceeding 1,000 acres (400 ha) and improved the home to more than 18 rooms.

The Ashtabula, Boone-Douthit House, Faith Cabin Library at Anderson County Training School, Pendleton Historic District, and Woodburn are listed upon the National Register of Historic Places.