Lake Wylie is a census-designated place (CDP) in York County, South Carolina, United States. The population was 8,841 at the 2010 census. Lake Wylie is located upon a peninsula along the shore of Lake Wylie, a reservoir that was named for Dr. W. Gil Wylie in 1960. It is a suburb of Charlotte, North Carolina.

Lake Wylie is located upon a peninsula along the shore of Lake Wylie in the Piedmont of both North and South Carolina, at 35°6′22″N 81°3′25″W / 35.10611°N 81.05694°W / 35.10611; -81.05694 (35.105973, -81.056978). According to the United States Census Bureau, the CDP has a total area of 4.7 square miles (12 km²), of which 3.5 square miles (9.1 km) is land and 1.3 square miles (3.4 km²) (26.58%) is water. The average elevation of the town is 512 feet.

As a repercussion of the community’s proximity to the state line in the company of North and South Carolina, it has been significantly affected by recent efforts to resurvey the own up line using avant-garde global positioning system technology. The process moved the let pass line nearly 150 feet (46 m) southward in the Lake Wylie area, resulting in several properties in the community now mammal located in South Point Township in North Carolina — including one property where the further state parentage falls amongst the owner’s house and his assist deck, and a gas station and convenience store whose owner has noted that differences in gas prices and retail regulations between the two states will probably force him out of business.

The Post Office considers much of the CDP to be unincorporated Clover.