Saltillo is a borough in Huntingdon County, Pennsylvania, United States. The population was 346 at the 2010 census.

Saltillo was named after the Mexican War Battle of Saltillo (23 October 1840). It was a major tanning center during the late 19th and to the lead 20th centuries. The Leas and McVitty Tannery was located here, known for tone hides. The main pedigree of the East Broad Top Railroad (EBT) was built through Saltillo in 1874. The railroad served the tannery as skillfully as a short-lived iron mine and an equally short-lived limestone quarry, both just southeast of town.

Saltillo was an important place on the EBT, acting as a base station for the long grade up to Broad Top Mountain. The EBT had a three-track yard, a station, a water tank and a turning wye located here. Just after the tilt of the 20th century a large ganister quarry was time-honored above Saltillo on Jacks Mountain by Mount Union Refractories (later United States Refractories and North American Refractories) to supply their reforest in Mount Union. In 1942 a spur was built from the EBT yard in Saltillo, which climbed the mountain to a tipple below the quarry. The branch was the steepest track upon the EBT and remained in benefits until the parentage closed in 1956. The quarry continued to accomplish into the 1970s, served by trucks. The EBT tracks in Saltillo are still in place. The water tank was burned by vandals in the late 1980s and the station was demolished in the mid-2000s after beast allowed to deteriorate to deplorable condition.

Around 1935 the skeleton of a mastodon was discovered in back the ball sports ground in Saltillo by two teenager men digging a drainage ditch. They excavated several bones, teeth and both tusks. They gave them to C.R. Cornelius the landowner, who difficult donated them to Penn State University where they can be seen today. In the 1990s Penn State reopened the dig and found even more bones that were missed during the first excavation.