Wynnewood is a city in Garvin County, Oklahoma, United States. It is 67 miles (108 km) south of Oklahoma City. The population was 2,212 at the 2010 U.S. census, compared to 2,367 in 2000. Located in what was then the Chickasaw Nation of Indian Territory, it began as a village called “Walner” in 1886, on the proposed route of the Gulf, Colorado and Santa Fe Railway. Railroad workers from Pennsylvania named the community for Wynnewood, a community uncovered of Philadelphia. The declare became official on April 6, 1887.

At the times of its founding, Wynnewood was located in Pickens County, Chickasaw Nation.

Wynnewood speedily became a broadcast town for the surrounding area. In 1887, Presbyterian missionary Mary Semple Hotchkins moved her school for Chickasaw kids from Cherokee Town to Wynnewood. In 1901, local citizens paid for building Indianola College. A promotional brochure published in 1907 called Wynnewood “the Queen City of the well-known Washita Valley.” It could soon boast of having an opera house, electric lights, telephones, and the thirty-room Eskridge Hotel.

The Eskridge Hotel continued in event until 1970, when it closed for good. In 1973, the Wynnewood Historical Society bought the three-story structure and converted it into a museum of local history. Hotel rooms have been decorated to depict energy in Oklahoma during the late 19th century and to the lead 20th century. In 1978, the former hotel was other to the National Register of Historic Places (NRHP).