Macomb is a town in Pottawatomie County, Oklahoma, United States. The population was 32 at the 2010 census, which represented a decline of 47.5 percent from the figure of 61 in 2000.

The present town of Macomb began as a community named Burnett upon the estate allotment owned by upon State Highway 59B bearing in mind the Atchison, Topeka and Santa Fe Railway Burnett, entrepreneurs from Burnett, moved to the current site. A pronounce office, originally designated as McComb, opened at the supplementary site upon May 29, 1903. The read out office and the town had been named for a Santa Fe engineer named Macomb. The names of the town and broadcast office were changed to Macomb on July 16, 1915, to precise the spelling.

By the stop of 1904, the town newspaper, McComb Herald, claimed the population was 350 and coined the nickname, “Queen City of South Pottawatomie County.” The 1910 census reported a population of forlorn 166. The 1920 census showed 281 residents. Hard become old came subsequently a prolonged drought caused the cotton crops to fail. In 1930, there were only 197 inhabitants. People moved away from the area; the 1950 census reported 123 residents. The number fell to 61 by the 2000 census.

Macomb is located at 35°8′52″N 97°0′30″W / 35.14778°N 97.00833°W / 35.14778; -97.00833 (35.147841, -97.008391). It is 10 miles (16 km) southwest of Tecumseh on State Highway 59B.