Ruffin is an unincorporated community located in Rockingham County, North Carolina. It is northeast of Reidsville, North Carolina, and southwest of Danville, Virginia, just off US 29 (future Interstate 785). It has a population of 419.

Neighboring communities and municipalities combine Reidsville, Eden, Pelham, Casville, and Wentworth. Ruffin had the first conventional volunteer blaze department in Rockingham County. Residents fabricate tobacco, vegetables and strawberries. The Place also had a gold mine. Churches in the community put in Ruffin United Methodist Church and Ruffin-Stacey Baptist Church.

With the talent of the vital Piedmont Railroad by the Confederate Government in in front 1864, the village of Ruffin experienced steady growth. Subsequently, Ruffin became an important middle of trade for both Rockingham and Caswell counties. Yet substantial accrual and commerce were to elude Ruffin. Instead the wealth was to locate a house in a smaller crossroads hamlet to the south by the broadcast of Reidsville. Tradition relates that layer in Ruffin was doomed because the large local landowners wanted to remain just that. Consequently, a booming town could not develop. From 1887-1897 though, Ruffin was incorporated as soon as its own mayor. The last mayor of Ruffin was Victor M. Holderby, who was an active supporter of the Ruffin Methodist Episcopal Church, South.

The community is named after Thomas Ruffin (1787–1870) an American jurist and Justice of the North Carolina Supreme Court from 1829 to 1852 and anew from 1858 to 1859. He was Chief Justice of that Court from 1833 to 1852. He lived in the community for a short while.