Tylertown is a town in Walthall County, Mississippi, United States. It is the county seat of Walthall County. The population was 1,609 at the 2010 census.

The town of Tylertown was first known as the Magee Settlement. It was settled by emigrants of the Magee and Thornhill families, who came from South Carolina. J. Thornhill acquired the first tract of house for the settlement upon September 20, 1816, after Native Americans were pushed out of the area. Cullen Conerly went there in 1850 and bought out the Garland Hart heap and received a declare office which was called Conerly’s state office. The amassing and make known office served as the social middle of the community for higher than a half century.

The town bore the say Conerly’s from 1848 to 1879. It was renamed as Tyler Town in honor of William G. Tyler; the pronounce was abbreviated to one word in 1894. Cullen Conerly sold his mercantile concentration to his brother-in-law Benjamin Lampton. He laid the launch of the mercantile concern of Tylertown.
Tylertown was part of Pike County until 1912, when Walthall County was formed from Pike and Marion counties. The Tylertown Times (local newspaper) was started in 1907. Tylertown Insurance Agency, Inc. has been serving Tylertown’s insurance needs past 1924. Luter’s Supply, established in 1944, is a retail middle for tubs, showers, and whirlpools. Jones Furniture opened in 1939. Tylertown’s oldest pharmacy, Pigott’s Drug Store, has been as regards since 1919. WTYL radio station came to Tylertown in 1969.

In interesting report about Tylertown and Walthall County was aligned in Maury Klein’s book “A Call to Arms” (Bloomsbury Press, Paperback edition, 2015). It seems that during World War II, the production and growing of food became problematic as both the United States and its allies were in need of good amounts of food. Production was lagging and crops were rotting in the fields for nonattendance of crop pickers – farm laborers either marched off to case or to factories where wages were far unconventional to those earned picking cotton – and the infatuation for more of everything was needed. Walthall County responded to the call to amass more of everything. The farmers left at the back produced what was termed “barn-bursting harvests, including 23 percent more cotton, 146 percent more hay, 110 percent more eggs, and a whopping 619 percent more truck crops. To celebrate, they decided to hold a “Food for Freedom Thanksgiving” early in October in Tylertown (population 1,100) the county chair and unaided post office”.