Luke is a town in Allegany County, Maryland, United States, located along the Potomac River just upstream of Westernport. Known originally as West Piedmont, the town is share of the Cumberland, MD-WV Metropolitan Statistical Area. The population was 85 as of the 2020 census.

The town of Luke was arranged in the prematurely 1770s after the dispensation of Hampshire County, West Virginia (at that times part of Virginia) in 1757. Among the first settlers to reach were the Davis brothers (Henry and Thomas), who expected a saw mill where the town of Luke now stands. The mill provided cross-ties to the Baltimore and Ohio Railroad as it pushed its rails westward through the Piedmont area of what is now West Virginia.

When the railroad suspended building in the 1880s, the Davis brothers disbanded and sold their property to William Luke, who founded the Piedmont Pulp and Paper Company there taking into consideration his sons in 1888. With this and supplementary paper mills they had built in West Virginia and Maryland, they formed the West Virginia Pulp and Paper Company in 1897. When the railroad needed a read out for the stop it established near the site, it used the name “Luke”.

The land upon which Luke was built was originally an island formed by a split in the Potomac River. It was known as West Piedmont and claimed by Piedmont, West Virginia until the river’s passageway changed and the house reverted to Maryland.