Perrysville is a town in Highland Township, Vermillion County, in the U.S. state of Indiana. The population was 456 at the 2010 census.

Perrysville was platted and surveyed in 1825 by James Blair upon a bluff on the west side of the Wabash River. The town is named for Commodore Oliver Hazard Perry, the hero of the Battle of Lake Erie. It became a local center for shipping products to New Orleans on flatboats via the Wabash, Ohio, and Mississippi Rivers, and it was also dexterous to get heavy equipment and manufactured items on steamboats. Prior to the advent of the railroad in the second half of the nineteenth century, the town’s location upon the river made for a successful community; it is reputed to have been the largest town in the company of Chicago and Terre Haute at the culmination of its success. The introduction of the Wabash and Erie Canal enhanced its importance even further; a sidecut gone locks allowed boats to be towed across the river to the town. Various roads intersected here, including a plank toll road from Danville, Illinois to the west, and stagecoach traffic became frequent. However, when the railroads did arrive, and bungled to pass through the town, it spelled the eventual grow less of the indispensable river traffic, and of the importance of the town of Perrysville.

The Perrysville read out office has been in operation in the past 1827.

Perrysville is located in the northeast part of the county upon the western banks of the Wabash River. Indiana State Road 32 passes through the town.