Whiskey Creek is a census-designated place (CDP) in Lee County, Florida, United States. The population was 4,842 at the 2020 census. It is part of the Cape Coral-Fort Myers, Florida Metropolitan Statistical Area.

Whiskey Creek is located in central Lee County at 26°34′39″N 81°53′23″W / 26.57750°N 81.88972°W / 26.57750; -81.88972 (26.577502, -81.889836). It is bordered to the north by the city of Fort Myers, the Lee county seat. To the west it is bordered by the Caloosahatchee River and by a little tributary, Whiskey Creek, for which the community is named. To the west across Whiskey Creek is the CDP of McGregor, while to the south is Cypress Lake and to the east are Villas, Pine Manor, and a southern extension of Fort Myers.

According to the United States Census Bureau, the Whiskey Creek CDP has a total Place of 1.6 square miles (4.2 km), of which 1.5 square miles (4.0 km²) are estate and 0.1 square miles (0.2 km), or 4.50%, are water.

As of the census of 2000, there were 4,806 people, 2,199 households, and 1,517 families residing in the CDP. The population density was 3,002.1 inhabitants per square mile (1,159.1/km²). There were 2,374 housing units at an average density of 1,482.9 per square mile (572.6/km). The racial makeup of the CDP was 96.57% White, 0.96% African American, 0.08% Native American, 0.71% Asian, 0.02% Pacific Islander, 0.44% from other races, and 1.23% from two or more races. Hispanic or Latino of any race were 2.29% of the population.