Manasota Key is a census-designated place (CDP) consisting mainly of the community of Englewood Beach in Charlotte County, Florida, United States. The population of the CDP was 1,326 at the 2020 census. It is part of the Sarasota-Bradenton-Punta Gorda Combined Statistical Area.

The name “Manasota Key” refers to an 11-mile-long (18 km) peninsula (transformed into a barrier island by the Gulf Intracoastal Waterway) that continues north into Sarasota County. The community of Englewood Beach occupies the Charlotte County share of the key, while the Sarasota County part of the peninsula contains the community of Manasota Beach. The key continues north as Caspersen Beach, extending as far as the Venice city limits.

Manasota is a portmanteau of “Sarasota” and “Manatee”.

The Manasota Key CDP is located in the northwestern corner of Charlotte County at 26°56′N 82°22′W / 26.933°N 82.367°W / 26.933; -82.367. As noted above, the barrier island of the similar name extends north capably into Sarasota County. Its western edge is the Gulf of Mexico, and to the east is Lemon Bay, an estuary. The community of Englewood Beach occupies most of the CDP, and it is united to the mainland by Beach Road, which crosses Lemon Bay to Englewood. The southern end of the CDP, which includes Manasota Key, Peterson Island, and Whidden Key, is covered by Stump Pass Beach State Park. Stump Pass is a channel that connects Lemon Bay to the Gulf of Mexico and separates Manasota Key from Don Pedro Island to the south. Grove City is located directly to the east across Lemon Bay from the south stop of Manasota Key.