Wyeville is a village in Monroe County, Wisconsin, United States. It is located on Wisconsin Highway 21. The population was 147 at the 2010 census.

The West Wisconsin Railway was authorized in 1876 to build from St. Paul, Minnesota through to achieve the Chicago and Northwestern Railroad at Elroy, Wisconsin. This railroad became the Chicago, St. Paul, Minneapolis and Omaha Railway (“The Omaha Road”) in 1880. At this location, a branch rail line was constructed eastward to Necedah. The location originally was named “Necedah Junction”. The local broadcast office was called Wyeville when established in 1890 and the first postmaster was Charles Brooks. The declare Wyeville is documented as a variation of “Wythe”, a county in Virginia. Eventually the name “Necedah Junction” was dropped in 1911 and the community was called the same name as the reveal office.

The railway junction became a crossing in 1911 for the lines of the Chicago and North Western Railway and its Omaha Road subsidiary. The Milwaukee, Sparta, and Northwestern Railroad, a supplementary of the Chicago and North Western Railway, began the “Air Line” or “Adams Cutoff” from Adams, Wisconsin towards Sparta, Wisconsin in 1910. This railroad used the parentage from Necedah to Wyeville as ration of this additional route. A genuine railroad wye was built at the railroad crossover, along gone an interlocking tower and railroad depot.

Until 1963, passengers of Twin Cities 400 and the Rochester 400 misrepresented trains there, as it was a scheduled transfer point for the two streamliners.