De Pere ( dee-PEER) is a city located in Brown County, Wisconsin, United States. The population was 25,410 according to the 2020 Census. De Pere is share of the Green Bay Metropolitan Statistical Area.

At the initiation of the first European, Jean Nicolet, who visited the place in 1634–1635, De Pere was the site of a polyglot agreement of several thousand attracted by the fishing at the first rapids of the Fox River. In 1671 French Jesuit traveler Père Claude-Jean Allouez founded the St. Francis Xavier Mission at the last set of rapids on the Fox River back it enters The Bay of Green Bay. The site was known as Rapides Des Pères (rapids of the fathers) which became radical day De Pere.

The present city of De Pere had its beginnings in 1836, when John Penn Arndt and Charles Tullar incorporated the De Pere Hydraulic Company and drew up the first plat of the town. In 1837, a popular vote acknowledged De Pere as the county seat of Brown County. It maintained this tilt until 1854, when different election moved the county chair to Green Bay. De Pere was incorporated as a village upon March 6, 1857.

Originally De Pere consisted solely of the community on the east side of the river. West De Pere upon the west side of the river was a town. In 1870 the Village of West De Pere was incorporated; in 1883 the Village of West De Pere became the City of Nicolet after voyageur Jean Nicolet; in 1887 the City of Nicolet became the City of West De Pere; and in 1890 the City of West De Pere consolidated behind the City of De Pere to form a single municipality.