Greenville is a census-designated place (CDP) in Augusta County, Virginia, United States. The population was 832 at the 2010 census. It is ration of the Staunton–Waynesboro Micropolitan Statistical Area.

As before as 1794, Greenville was platted and at odds into 14 lots of 1-acre (4,000 m) and sold by Thomas and Jane Steele. Greenville soon became a unconditionally busy stagecoach stop. This was because there were 3 major roads everything intersecting at or close Greenville. One road linked Greenville as soon as Staunton, another ran from Waynesboro to Middlebrook, and the south road led to Midway (now Steeles Tavern), Fairfield, and Lexington. The town slowly grew, and by 1810, the population had grown to 162, comparing to Staunton’s 1225, and Waynesboro’s 250. An 1835 account of Greenville said that it had an extensive manufacturing flour mill and a woolen manufactory, two physicians in the area, contained 50 dwelling houses, 3 general stores, 2 taverns, 1 academy, 2 tanyards, 2 saddlers, 2 tailors, 1 blacksmith shop, 1 cabinet maker, 1 wheelwright, 1 saddle tree maker, 3 home carpenters, 1 hatter, and 4 boot and shoe makers. The population was virtually 250 in 1928.

Bethel Green and Clover Mount are listed upon the National Register of Historic Places.

Kate Smith (1907-1986), an immensely popular American radio singer of the Great Depression and World War II years, was born in Greenville. A statue of her stands outside the Wachovia Spectrum in Philadelphia because her rendition of “God Bless America” has long been considered a good luck charm for important games of the Philadelphia Flyers hockey team.