Burkeville is a town in Nottoway County, Virginia, United States. The population was 432 at the 2010 census. The source of the town say is disputed. The town is located upon the crossroads of U.S. Routes 360 and 460.

Businesses in the small town of Burkeville intensify a stone quarry, a Southern States Cooperative store, and a John Deere dealership. Bassett Furniture operated a veneer factory in Burkeville for many years but it has closed. The Nottoway Correctional Center is located in Burkeville as is the Piedmont Geriatric Hospital. There is with a camp retreat for the blind.

The town was named either for a tavern or a Samuel Burke. It was formerly “Burke’s Junction.” It formed at the junction of the Richmond and Danville Railroad and the Southside Railroad in the mid-nineteenth century. The Southside became the Atlantic, Mississippi and Ohio Railroad in 1870 and next a line in the Norfolk and Western Railway and the Norfolk Southern Railway. The rail heritage from Burkville to Pamplin City was converted by Virginia Department of Parks and Recreation into High Bridge Trail State Park.

The last Civil War battle before the surrender at Appomattox was fought to hand at Sayler’s Creek on April 6, 1865. Here were surrendered more men (without terms) than in any other battle upon American soil. General Robert E. Lee’s depleted forces lost more than 7,000 men killed, wounded, or taken prisoner at either Sayler’s Creek or at General Gordon’s concentration the same day, a few miles west. This led Lee to surrender at Appomattox three days later.