Jeffersonville is a village in the town of Cambridge, Vermont, United States. The population was 750 at the 2020 census.

The village was originally called “Cambridge Center”. The publicize was distorted to “Jeffersonville” in 1827 to great compliment Thomas Jefferson. The village was incorporated in 1897.

According to the United States Census Bureau, the village has a total area of 0.81 square miles (2.1 km), of which 0.03 square miles (0.07 km²), or 3.25%, is water. The village is located close the geographic center of the town of Cambridge, along the south bank of the Lamoille River where it is joined by the Brewster River. Jeffersonville is 30 miles (48 km) northeast of Burlington via Vermont Route 15. Jeffersonville sits at 1,060 feet (320 m) above sea level, surrounded by future standing mountains, such as Mount Mansfield (the highest top in Vermont at 4,393 feet (1,339 m)), 7 miles (11 km) to the south.

Jeffersonville has a humid continental climate (Köppen Dfb), with very frosty winters and warm, humid summers. The monthly daily average temperatures ranges from 12 °F (−11.1 °C) in January to 64.4 °F (18 °C) in July. The annual precipitation is significant, averaging 72.3 inches (1703.6 mm) and is well-distributed throughout the year, but the latter months are the wettest. The town’s location east of Lake Champlain sometimes accounts for localized snow squalls, producing taking place to 18 inches (45.7 cm) in 12 hours upon rare occasions. Annual snowfall is significant, averaging 331.4 inches (841.2 cm). Extremes have ranged from −38 °F (−38.8 °C) on January 28, 1994 to 89 °F (31 °C) on June 28, 2003 and July 26, 1989. The most snowfall from a single storm is 73.1 inches (185.7 cm), which fell January 2–4, 2010.