Scottsville is a city in Harrison County, Texas, United States. The population was 376 at the 2010 census, up from 263 at the 2000 census. Scottsville’s population in 2020 decreased to 334.

The area was initially fixed by William Thomas Scott, his wife Mary Rose, and other members of their families in June 1840. He quickly acquired several large parcels of land, established five cotton plantations, including Scottsville Plantation, his residence, constructed by slaves. Scott’s lavish plantation was said to be identical to Jefferson Davis’ mansion in Mississippi, and he eventually became the largest slave owner in Harrison County.

On August 4, 1869, Scottsville was granted a pronounce office. The community had an estimated population of 300 in 1929. In 1936, a historical marker was erected in Scottsville to commemorate both the founding of the community and the centennial of Texas Independence. During the Great Depression, the population fell to a low of 50, but had recovered to 260 by the 1950s. The number of inhabitants remained steady throughout the latter half of the twentieth century not supportive of Uncertain, Texas.

Scottsville is located at 32°32′10″N 94°14′30″W / 32.53611°N 94.24167°W / 32.53611; -94.24167 (32.536098, –94.241611), along Farm Roads 1998 and 2199, north of U.S. Highway 80 in east-central Harrison County. It is 8 miles (13 km) east of the middle of Marshall, the county seat. US 80, which forms the southern connect of Scottsville, leads west into Marshall and east 11 miles (18 km) to Waskom. Interstate 20 passes 3 miles (5 km) south of the center of Scottsville, with entrance from Exit 624 (Farm Road 2199).