Nixon is a city, self-described as a “compact neighborhood,” at US 87 in Gonzales and Wilson counties; alongside the Clear Fork Creek in the Juan J. Tejada League, in the U.S. state of Texas. Approaching 100 city blocks, the Nixon urban-area is defined by its schools at its north-end in the neighborhood of Rancho; with the southwest boundary hosting its industrial park and meat packing facilities, upon the 87-corridor towards Pandora and the county seat of Floresville.

The population was 2,385 at the 2010 census. Nixon is located primarily within Gonzales County; however, most of its major employers and assets are alongside the eastern Wilson County line. The city has a total area of 1.6 square miles (4.1 km²), all land. The Wilson County portion of Nixon is part of the San Antonio Metropolitan Statistical Area.

Nixon was formed across the landholdings of the Nixon family through the end of the 19th century, beginning as a 14,000 acre plantation south of Luling and north of Belmont. In the early 20th century through the present day, Nixon continually consolidated southward at John T. Nixon’s land closer to the original settlements of Cuero, Goliad and Indianola, once acting as a rail station; this confluence once having the original name of “Rancho,” so named for its free-range cattle industry.

The city is served primarily by employers that include a publicly-traded oil refinery, a chicken slaughterhouse, and its municipal services, especially the Nixon-Smiley Consolidated Independent School District. In 2018, the aggregate income of urban Nixon was an estimated $58,035,500. In 2019 according to the Texas Department of Transportation, the aggregate annual-average-daily-traffic (AADT) of urban Nixon was rated at 22,928 vehicles.