Melissa is a city in Collin County, Texas, United States. The population was 4,695 at the 2010 census, up from 1,350 at the 2000 census; in 2020, its population grew to 13,901.

Some of Melissa’s first settlers came from the old-fashioned Highland community, two and a half miles north of present-day Melissa. C.H. Wysong, a blacksmith, was one of the old-fashioned settlers. A publicize office was traditional in 1853 at Highland. The Houston and Texas Central Railroad arrived in Melissa in 1872 and usual a depot. The town was laid out at this time. The railroad encouraged many families to come to Melissa. The town is believed to have been named for the daughter of a railroad executive, George A. Quinlan (1838–1901) of the Houston and Texas Central Railroad. There is some disagreement nearly this, as others argue that the town was named after Melissa Huntington, daughter of C. P. Huntington, another Famous railroad executive. Anna, Texas, is named after Anna Elizabeth Quinlan (1878–1952), the only daughter of George Austin Quinlan and his wife Mary Kate Saunders (1851–1884). Quinlan, Texas, is named after George Austin Quinlan himself.

The first learned in Melissa was built upon land purchased in 1882 by trustees James Graves, John Gibson, and George Fitzhugh, who were ahead of time settlers of the area. The first assistant professor was Mary Huckerston, who taught there for five years. The educational began later 38 pupils. Church services were held there for everything faiths upon Sundays. A two-story brick schoolhouse was built upon this site in 1910 to accommodate increase brought by the railroad.

Melissa was an important shipping dwindling in the ahead of time 1900s. Corn, wheat, alfalfa hay, wood, and livestock were whatever sent out upon the railroad.