Lake Cherokee is an unincorporated community and census-designated place (CDP) in Gregg and Rusk counties, Texas, United States. Its population was 2,980 as of the 2020 census. Lake Cherokee is located 12 miles Southeast of Gregg and Northeastern Rusk counties upon Cherokee Bayou. The lake is owned by the Cherokee Water Company to supply water for municipal, industrial, and recreational purposes. It has a power of 68,700 acre-feet. The lake impounds Cherokee Bayou. The top of the dam is at the height is 295 feet above the average sea level, but it has a max design of 291 feet above the average sea level. Lake Cherokee is located 12 miles Southeast of Gregg and Northeastern Rusk counties upon Cherokee Bayou. The lake is owned by the Cherokee Water Company to supply water for municipal, industrial, and recreational purposes.

The community consists of housing increase that surrounds Lake Cherokee, a reservoir upon Cherokee Bayou, an east-flowing tributary of the Sabine River. Texas State Highway 149 forms the northern affix of the CDP; the highway leads northwest 12 miles (19 km) to Longview and southeast 24 miles (39 km) to Carthage.

According to the U.S. Census Bureau, the community has an Place of 16.525 square miles (42.80 km); 12.239 square miles (31.70 km²) of its Place is land, and 4.286 square miles (11.10 km) is water. About three-quarters of the area of the CDP is within Rusk County, with the remainder in Gregg County. The county extraction follows the center of the lake for the belittle half of its reach. The upstream half of the lake is completely within Rusk County.

As of the 2020 United States census, there were 2,980 people, 1,424 households, and 1,065 families residing in the CDP.