Fowlerton is a census-designated place (CDP) in La Salle County, Texas, United States. Its population was 55 at the 2010 census.

Fowlerton is named for two brothers who approved the community roughly 1910. By 1914, Fowlerton peaked in population at vis-а-vis 1,000, and had telephone service. Farmers faced droughts and low prices. The Fowler brothers had described themselves as “colonizers” and widely advertised the town. They soon faced lawsuits from disgruntled settlers. By 1925, the population had declined to just about 600, and never recovered. The San Antonio, Uvalde and Gulf Railroad, now portion of Union Pacific, brought only the theater prosperity to Fowlerton.

Fowlerton is located in northeastern La Salle County at 28°27′53″N 98°48′42″W / 28.46472°N 98.81167°W / 28.46472; -98.81167 (28.464840, -98.811642). It is bordered to the east by McMullen County. Texas State Highway 97 passes through the community, leading north 29 miles (47 km) to Charlotte and west 27 miles (43 km) to Cotulla. Texas State Highway 72 leaves Highway 97 2 miles (3 km) north of Fowlerton and leads east 39 miles (63 km) to Three Rivers. San Antonio is 75 miles (121 km) north of Fowlerton, Corpus Christi is 114 miles (183 km) to the southeast, and Laredo is 100 miles (160 km) to the southwest.

According to the U.S. Census Bureau, the Fowlerton CDP has a total Place of 2.2 square miles (5.6 km), of which 0.004 square miles (0.01 km²), or 0.22%, are water. The Frio River runs along the northern edge of the community, leading east to the Nueces River at Three Rivers.