Donna is a city in Hidalgo County, Texas, United States. The population was 16,797 at the 2020 census.

Donna is in southeastern Hidalgo County, 11 miles (18 km) east of McAllen, in territory that was contracted to Lino Cabazos as ration of the La Blanca home grant on May 19, 1834, by the Mexican acknowledge of Tamaulipas. The Cabazos relations inhabited the Place for at least twenty years after taking possession of the land, and their descendants continued to stir in the Place into the twentieth century. The first known Anglo-American settler was John F. Webber, who, accompanied by his wife Sylvia (Hector), a former slave, settled in the Place in 1839. The Webbers moved to the area in order to escape persecution for their interracial marriage.

Several families from northern states, including the Ruthven, Champion, and Hooks families, settled the area. Thomas Jefferson Hooks arrived in the Lower Rio Grande valley in 1900 and the behind year moved his relations to Run in southeastern Hidalgo County. In May 1902 he helped to form the La Blanca Agricultural Company, which purchased 23,000 acres (93 km) fronting the river 2 miles (3 km) east and west of the site of present Donna and extending north 18 miles (29 km). He gave ration of his buy to his 21-year-old daughter, Donna Hooks Fletcher, a divorcée.

She arranged in the Place and conventional the Alameda (Grove) Ranch. Fletcher stocked the ranch subsequent to Jersey cattle purchased from the Lassater Ranch in Falfurrias and ran a successful butter business. The Hidalgo and San Miguel Extension (later called the Sam Fordyce Branch) of the St. Louis, Brownsville and Mexico Railway reached the site in July 1904, when the town was founded. In 1907 the town acknowledged a depot and was named “Donna” in tribute of Donna Fletcher, who was postmistress subsequent to the Donna post office opened in 1908.