Saltillo is a town in Hardin County, Tennessee, United States. The population was 303 at the 2010 census. Saltillo is located upon the left bank of the Tennessee River, about 12 miles north of Savannah.

Saltillo was founded by Thomas Shannon in October, 1822. He had left Davidson County, Tennessee and arrived in the Place on a keelboat with sufficient provisions to last one year, two men, Colonel John Holland and Parkerson Mitchell, to support him, and four black men. The men arrived via Tennessee River and built camp practically half a mile from the river. Shannon’s wife and seven kids came by home with a objective of forty cattle. This cattle would further as the starting narrowing for Shannon to lift cattle for income, but the cattle were unable to adjust to the fine-tune in their character and feeding. Within three months of grazing, 39 of the 40 cattle were dead. Shortly after the Shannon family’s arrival, Shannon and his sons built a log cabin in 1825, serving as the first home built in Saltillo. Shortly thereafter a store-house was built by Smith Hawkins for teetotal goods to be distributed, which were sold out within three months. The Place where this store-house was built is now called Hawkin’s Landing.

More settlers came to the Place and another buildup was built a quarter mile south of the first hoard by Hawkin’s brother, Perry. The first man to be killed in town was Simpson Lee, who was thrown off his horse. Barges began regularly delivering goods and residents would travel as far-off as the Duck River for a grist mill. In 1842 Thomas Davy purchased the land once owned by Thomas Shannon and it was named Davy’s Landing. In 1849 Davy leased the house to Scott Terry, who renamed the area Saltillo. The town was named Saltillo after Saltillo, Mexico by Terry, who was a veteran of the Mexican–American War. The Saltillo broadcast office was opened in 1850. Saltillo was incorporated in 1870.

Saltillo is located at 35°22′50″N 88°12′44″W / 35.380579°N 88.212119°W / 35.380579; -88.212119.