Puryear is a city in Henry County, Tennessee, United States. The population was 671 at the 2010 census.

Puryear is located in northern Henry County at 36°26′41″N 88°20′2″W / 36.44472°N 88.33389°W / 36.44472; -88.33389 (36.444853, -88.333770). U.S. Route 641 passes through the east side of the city, leading north 4 miles (6 km) to Hazel, Kentucky, and south 10 miles (16 km) to Paris, the Henry county seat. Tennessee State Route 140 passes through the middle of Puryear, leading east 12 miles (19 km) to U.S. Route 79 close Paris Landing State Park on Kentucky Lake, and west 8 miles (13 km) to SR 69 close Jones Mill.

According to the United States Census Bureau, Puryear has a total Place of 0.93 square miles (2.4 km), all land. The Tennessee Valley Divide runs along the western edge of the city; most of Puryear drains north via the East Fork of the Clarks River, eventually reaching the Tennessee River just south of its confluence when the Ohio River, while the westernmost portion of Puryear drains west via Clear Creek to the North Fork of the Obion River, a tributary of the Mississippi.

As of the census of 2000, there were 667 people, 284 households, and 191 families residing in the city. The population density was 730.0 people per square mile (283.0/km²). There were 328 housing units at an average density of 359.0 per square mile (139.2/km). The racial makeup of the city was 95.65% White, 2.70% African American, 0.15% Native American, 0.45% Asian, 0.45% from additional races, and 0.60% from two or more races. Hispanic or Latino of any race were 0.75% of the population.