Wellsboro is a borough in Tioga County, Pennsylvania. The borough was founded by Benjamin Wistar Morris. It is located 52 miles (84 km) northwest of Williamsport. The population was 3,472 at the 2020 census.

Early in the 20th century, Wellsboro was the shipping dwindling and trade middle for a large area. It had fruit evaporators, flour and woolen mills, a milk-condensing plant, marble works, saw mills, foundry and robot shops, and manufactories of clip glass, chemicals, rugs, bolts, cigars, carriages, and furniture. In 1900, 2,945 people lived here; in 1910, 3,183 lived here. It is the county seat of Tioga County, and also home to the Grand Canyon of Pennsylvania.

Wellsboro was contracted in 1806 and incorporated in 1830 and was named in award of Mary Wells, wife of one of the original settlers, Benjamin Wistar Morris. The town was the house of George W. Sears (1821 – 1890), a sportswriter for Field & Stream magazine in the 1880s and an ahead of time environmentalist. His stories, appearing below the pen name “Nessmuk”, popularised self-guided canoe camping tours of the Adirondack lakes in get into lightweight solo canoes and what is today called ultralight camping. Wellsboro was plus the site of one of the first factories where roomy bulbs were mass-produced, using machines whose design remains in fact unchanged from the in advance 20th century later the Corning company usual the plant in the town.

The Robinson House, Jesse Robinson House, Wellsboro Armory, and Wellsboro Historic District are listed on the National Register of Historic Places.