Titusville is a city in the far-off eastern corner of Crawford County, Pennsylvania, United States. The population was 5,262 at the 2020 census. Titusville is known as the birthplace of the American oil industry and for a number of years was the leading oil-producing region in the world. It was in addition to notable for its lumber industry, including 17 sawmills, as well as its plastic and toolmaking industries. It is part of the Meadville micropolitan area.

The Place was first settled in 1796 by Jonathan Titus. Within 14 years, others bought and improved home lying near his, along the banks of what is now Oil Creek. Titus named the village Edinburg(h), but as it grew, the settlers began to call the hamlet Titusville. The village was incorporated as a borough in 1849. It was a slow-growing community until the 1850s, when petroleum was discovered in the region.

Oil was known to exist there, but there was no practical pretension to extract it. Its main use at that period had been as a medicine for both animals and humans. In the late 1850s, the Seneca Oil Company (formerly the Pennsylvania Rock Oil Company) sent Col. Edwin L. Drake to start drilling on a fragment of leased estate just south of Titusville, near what is now Oil Creek State Park. In the summer of 1859, Drake hired a salt well driller, William A. Smith. They had many difficulties but, on August 27, at the site of an oil spring just south of Titusville, they finally drilled a without difficulty that could be commercially successful.

Teamsters were needed suddenly to transport the oil to markets. In 1862, the Oil Creek & Titusville Railroad was built with Titusville and Corry, where the product was transferred to larger east-west railroad lines. In 1865, pipelines were laid directly to the lineage and the request for teamsters roughly ended. The next year the railroad line was extended south to Petroleum Centre and Oil City. The Union & Titusville Railroad was built in 1865. That extraction became portion of the Philadelphia and Erie Railroad in 1871. That fall, President Ulysses S. Grant visited Titusville to view the important region.