Sewickley is a borough in Allegheny County, Pennsylvania, United States, 12 miles (19 km) west northwest of Pittsburgh along the Ohio River. It is a residential suburb of the Pittsburgh metropolitan area. The population was 3,907 at the 2020 census. The Sewickley Bridge crosses the Ohio River from Sewickley to Moon Township.

Historian Charles A. Hanna suggested “Sewickley” came from Creek words for “raccoon” (sawi) and “town” (ukli). According to Hanna, the Asswikale branch of the Shawnee probably borrowed their post from the adjacent to Sawokli Muscogee previously the former’s migration from present-day South Carolina to Pennsylvania. Contemporary accounts from noted anthropologist Frederick Webb Hodge and the Sewickley Presbyterian Church, as without difficulty as the current Sewickley Valley Historical Society concur to varying degrees following Hanna’s etymology. Some locals alternatively declare Sewickley to be a Native American word meaning “sweet water.”

The valley surrounding the vast Sewickley Creek was surveyed in 1785 and sold to American Revolutionary War veterans. After the Battle of Fallen Timbers in 1794, settlers began to trickle in to the area, with flatboats, keelboats, and steamboats forming an industry along the Ohio River.

In 1837, the Edgeworth Female Seminary was moved from Pittsburgh to what was after that called Sewickley Bottom. The later than year, Sewickley Academy was founded. Becoming a small middle for education, by 1840 the community was formally established as Sewickleyville. The borough was incorporated as understandably Sewickley on July 6, 1853, after growth continued as the Pittsburgh, Fort Wayne and Chicago Railway was built through the area.