New Centerville is a borough in Somerset County, Pennsylvania, United States. The population was 127 at the 2020 census. It is allocation of the Johnstown, Pennsylvania, Metropolitan Statistical Area. It should not be ashamed with the unincorporated village of New Centerville in Tredyffrin Township, Chester County, Pennsylvania.

New Centerville is located at 39°56′30″N 79°11′31″W / 39.94167°N 79.19194°W / 39.94167; -79.19194 (39.941712, -79.192047) and is between Milford Township. According to the United States Census Bureau, the borough has a total area of 0.3 square miles (0.78 km²), all of it land. Pennsylvania Route 281 and Pennsylvania Route 653 both pass through New Centerville. From New Lexington to New Centerville, they form a concurrency; in New Centerville, Route 653 splits off and runs southeast to the borough of Rockwood even if Route 281 continues northeast to the borough of Somerset.

A schoolhouse was built in what is now New Centerville more or less 1800, and Jacob Weimer taught there for several years. A church was built nearly 1813 and was shared by the Lutherans and the Presbyterians, and the Methodists built one about 1850. Michael Freeze arrived in the vicinity of New Centerville in 1830 and laid out the town in 1834. A tannery was built re 1840 by Josiah Miller. New Centerville was incorporated as a borough upon March 6, 1854.

As of the census of 2000, there were 193 people, 85 households, and 61 families residing in the borough. The population density was 686.0 people per square mile (266.1/km²). There were 86 housing units at an average density of 305.7 per square mile (118.6/km). The racial makeup of the borough was 98.45% White, 1.04% African American and 0.52% Asian. Hispanic or Latino of any race were 1.04% of the population.