Greensboro is a borough in Greene County, Pennsylvania, United States. The population was 267 at the 2020 census, up from 260 at the 2010 census.

Greensboro is located in southeastern Greene County at 39°47′34″N 79°54′44″W / 39.79278°N 79.91222°W / 39.79278; -79.91222 (39.792911, -79.912087). It is situated upon the west bank of the Monongahela River, opposite New Geneva and the mouth of George’s Creek. It is bordered by Monongahela Township in Greene County to the north and west, and by Nicholson Township in Fayette County to the south and east, across the Monongahela. The county and township link up follows the center of the river. The closest road bridges beyond the river are the Masontown Bridge on Pennsylvania Route 21, 8 miles (13 km) north of Greensboro by road, and the Albert Gallatin Memorial Bridge upon Pennsylvania Route 88 at Point Marion, 6 miles (10 km) south of Greensboro.

According to the United States Census Bureau, the borough has a total area of 0.15 square miles (0.38 km), of which 0.11 square miles (0.28 km²) are estate and 0.04 square miles (0.10 km), or 26.06%, are water.

Like much of the region, Greensboro can relish its roots put taking place to to Native American settlement, to the Mingo tribes of the Northern Iroquois. What was to far ahead become Greensboro was first known to the Mingo as “Delight”, so named in confession of the rich farmland that stretched along the banks of the Monongahela River. As beforehand as 1752, settlers from the east and south began to stake their claims in the lands along the Monongahela. The first white settler of Delight was explorer-trader John Badolet, who was a near friend of John Minor. Minor was the leader of the first activity to be consistent with in the Place presently known as Mapletown, to the northwest of Greensboro in Monongahela Township.