Brookville is a borough in Jefferson County in the U.S. state of Pennsylvania, 80 miles (130 km) northeast of Pittsburgh. As of the 2010 census, the population was 3,933. Founded in 1830, it is the county seat of Jefferson County

The Place was initially granted in the late 1790s on the dawn of brothers Joseph and Andrew Barnett, as competently as their brother-in-law Samuel Scott, who together time-honored the first settlement at the confluence of the Sandy Lick and Mill Creeks in the Place now known as Port Barnett. The first non-Native American settler of the land within the eventual town limits was Moses Knapp, who built a log house at the confluence of North Fork Creek and Sandy Lick Creek (which form Redbank Creek) in 1801.

The 105th Pennsylvania Infantry Regiment, also known as the Wildcat Regiment, was a volunteer infantry regiment that served in the Union Army during the American Civil War and was raised by Amor A. McKnight of Brookville. The Regiment fought in several engagements, including Chancellorsville and Spotsylvania Court House.

Brookville’s main source of economic evolve throughout the 19th century was the lumber industry. Brookville’s many creeks and its association to larger rivers (the Clarion to the north, which, like the Redbank, flows to the Allegheny) allowed for extensive construction of lumber mills along the watersheds and the in limbo of timber to markets in Pittsburgh. The town enjoyed great economic exploit during the late 19th and in advance 20th centuries, serving as home to several factories, breweries, an important railroad End for local coal and timber, and briefly the Twyford Motor Car Company, which operated from 1905 to 1907 and produced the world’s first four-wheel aim automobile.