Shaniko (, SHAN-i-koh) is a city located in Wasco County, Oregon, United States, on U.S. Route 97 and practically 8 miles (13 km) north of Antelope. The population was 36 at the 2010 census.

Shaniko is in Wasco County, in north-central Oregon, at the intersection of U.S. Route 97 and Oregon Route 218. The city is 69 miles (111 km) north of Redmond and 131 miles (211 km) east of Portland. According to the United States Census Bureau, the city has a total area of 0.50 square miles (1.29 km), all of it land.

The city is at an elevation of 3,343 feet (1,019 m). On the high plateau upon which Shaniko was built, the soil is skinny and the vegetation sparse, consisting mainly of sagebrush, bunchgrass, and occasional junipers. Many peaks of the Cascade Range, including Hood, Jefferson, Adams, St. Helens and Rainier, are visible from the city.

The first European Americans came to the Shaniko Place after the discovery of gold in Canyon City, Oregon, in 1862. The route to Canyon City started at the early treaty of The Dalles, 190 miles (310 km) away. Camps were made wherever water could be found. One camp, which became the gardening community of Bakeoven, was contiguously associated taking into account the forward-thinking town of Shaniko, while unusual camp, Cross Hollow, was within the gift Shaniko city limits. In 1867, following complaints of bitter Indians and fright of robbery of those transporting gold, the State of Oregon expected a comply from the United States direction to build a military wagon road from The Dalles to Fort Boise in what was after that Washington Territory, (now Idaho). Following this road, homesteaders began claiming house in Central Oregon that past had been fairly inaccessible.