Bison is an unincorporated community and census-designated place (CDP) located upon US Highway 81 in Garfield County, Oklahoma, United States, consisting of a 30-acre (12 ha) town plat. As of the 2010 census, it had a population of 65.

The community was named for approachable Buffalo Springs, a historic stagecoach End and a watering hole on the Chisholm Trail located approximately a mile north of Bison. Bison is house to a Catholic community, part of St. Joseph’s parish under the Archdiocese of Oklahoma City. The church was erected in 1909, followed by a two-story brick scholastic building operated by the Sisters of the Divine Providence from 1911 to 1934, when the Adorers of the Blood of Christ took over.

Bison’s economy is agricultural and oil-based in the proclaim of oil wells on several farms and grain elevators by the Bison Cooperative Association, Star Mill and Burrus Mill companies. Bison was home to Bison State Bank from 1900 until 1933, when it closed due to the Great Depression. The Hotel Woodring was traditional in 1900 by Irvin and Ella Woodring, the parents of Irvin “Bertie” Woodring, for whom Enid Woodring Regional Airport is named. The say office opened on August 31, 1901. The Bison Mercantile Company was originally traditional as a grocery deposit by W.J. Scrichfield in 1900 and operated until 1958 in the circulate of it was purchased by the Bison Cooperative Association. The co-op was standard in 1920, the similar year that Oklahoma Gas & Electric brought electricity to the town.

Bison is located in southern Garfield County upon the west side of US Highway 81, which leads north 14 miles (23 km) to Enid, the county seat, and south 6 miles (10 km) to Hennessey. According to the U.S. Census Bureau, the Bison CDP has an area of 1.06 square miles (2.74 km), all land.