Perrysburg is a city located in Wood County, Ohio, United States, along the south side of the Maumee River. The population was 25,041 at the 2020 census. Part of the Toledo metropolitan area, the city is 12 miles (19 km) southwest of Toledo. It served as the county chair from 1822 to 1868, and it is nevertheless the second-largest city in Wood County. After Bowling Green was designated as county seat, it surpassed Perrysburg in size.

Perrysburg was surveyed and platted by a federal survey team in summer 1816. A local legend has held that it was meant by noted architect Charles Pierre L’Enfant, after he planned Washington, DC, but this has not been supported by fact.

Perrysburg lies near the center of the Twelve Mile Square Reservation, a tract of estate ceded in 1795 to the United States of America by the Odawa people like their crush in the Northwest Indian Wars. They had occupied this territory in the past the incline of the 18th century, after having settled in the region of the French trading proclaim at Fort Detroit. Also known as the Ottawa, they had controlled much of the territory along the Maumee River in present-day northwestern Ohio.

In 1810, early European-American settlers here were Major Amos Spafford (1753-1818), his wife Olive (1756-1823), and their four children. In 1796, Spafford, a original of Connecticut, was a surveyor for the Connecticut Land Company. He drew the first map laying out Cleveland and named the city. He left there in 1810 following attainment as US Customs Collector and postmaster for the new harbor at the Foot of the Rapids of the Miami of the Lake Maumee River. Two years later, 67 families lived in the area, but most fled at the outbreak of the War of 1812.