Pancoastburg (originally known as Pancoastburgh) is an unincorporated community and census-designated place (CDP) in Madison Township, Fayette County, Ohio, United States. It is located at 39°37′28″N 83°15′56″W / 39.62444°N 83.26556°W / 39.62444; -83.26556Coordinates: 39°37′28″N 83°15′56″W / 39.62444°N 83.26556°W / 39.62444; -83.26556, along Ohio State Route 207, about 6 miles (10 km) south of Mount Sterling. As of the 2010 census the population of Pancoastburg was 87.

Samuel Pancoast customary a carding mill at Pancoastburg in the 1820s. It was a stage coach stop along the Chillicothe-Urbana line. The land was next owned by Isaiah Pancoast, who platted the town. The settlers of the Place split into two groups, one organization stayed in Pancoastburg, and the further settled Yankeetown a sudden distance away. About this time, the post of the community was tainted to Waterloo. Yankeetown was short lived, and the settlers that had split off returned to the native site. By 1860, the name of the community was changed encourage to Pancoastburg. The Pancoastburg pronounce office was originally normal as “Pancoastburgh” on August 19, 1847. The declare was tainted to “Pancoastburg” on May 16, 1893, and was discontinued on December 15, 1920. The mail encouragement is now sent through the Washington Court House branch.

The Jackson Mound is located 4 miles (6 km) north of Pancoastburg; built by the Adena culture, it is the last Native American mound in existence in Fayette County.