Higginsport is a village in Lewis Township, Brown County, Ohio, United States, along the Ohio River. The population was 251 at the 2010 census.

Col. Robert Higgins was a Revolutionary War overseer who had received 1,000 acres (400 ha) of estate in Brown County, Ohio for his sustain to his country. He and his relations first moved onto the estate in 1799, building a little crude cabin near what is now Higginsport. On September 1, 1804, Higgins started surveying a other community named White Haven upon his land, and that similar month it was platted and recorded in Williamsburg. The community never grew, and after a number of years, was abandoned. On February 28, 1816, Higgins once more replatted the community, this time subsequently 114 lots, and renamed it Higginsport. The street layout mostly followed the indigenous White Haven lines. Higgins furthermore donated a small cemetery (his wife the first person buried here) to the town, as with ease as house in the center of town for a public park, and about 15 acres (6.1 ha) on the edge of town called White Oak Bottom. The first church was organized in 1818, and by 1819, there were 6 cabins here and a population of 6, but the community was growing. In 1828, a small store opened, which was expanded in 1832. In 1835, the first brick home was built in town, by Jesse Dugan, then owner of the store. Located at the corner of Water and Brown Streets, it was yet standing in 2013. The Higgingsport Post Office was established upon January 24, 1829, with a Mr. Roberts, the town tailor, as Post Master. Two more stores were opened in town in 1835 and 1839.

In 1880, the population was 862, and as of 1883, the community was described as a “thriving village”, containing in sum five general stores, one clothing store, two drug stores, two tin shops, one hardware store, four fancy stores, one tobacco store, several grocery stores, two blacksmiths, one wagon-maker, one tavern, a grist mill, a distillery, five doctors, and two hotels.

White burley tobacco was first grown close Higginsport in 1864 from seed brought from Kentucky, and by the 1880s, the local economy was largely based upon it. In 1883, there were seventeen tobacco warehouses and 32 exchange tobacco buyers, shipping approx. 2 million pounds annually all along the Ohio River to New Orleans.