East Palestine ( PAL-ə-STEEN) is a village in northeastern Columbiana County, Ohio, United States. The population was 4,761 at the 2020 census. Located upon the state’s link up with Pennsylvania, East Palestine is roughly 20 miles (31 km) south of Youngstown and 40 miles (64 km) northwest of Pittsburgh. It is allowance of the Salem micropolitan area.

East Palestine is located along the Norfolk Southern Railway, and has a freight train station. From the 1870s until the mid 1960s, the city was home to industries in ceramics and tire manufacturing.

East Palestine was founded in 1828 as Mechanicsburg, and incorporated as a village in 1875 as East Palestine after the biblical region of Palestine. The reveal was misrepresented as ration of a religious nomenclature in the area, including communities such as Enon Valley and New Galilee, Pennsylvania (Palestine, Ohio was already an incorporated community). Having reached a population of 5,000, East Palestine operated as a statutory city from 1920 until 2011, when it reverted to village status due to declining population.

By the 1920s, railroad services of the city consisted of the four track Pennsylvania Railroad system. Switches from the Pittsburgh, Lisbon and Western Railroad within one mile of the corporation limits connected in the expose of the Pittsburgh and Lake Erie Railroad and New York Central Railroad. The city’s leading industries were the fabricate of pottery and automobile tires by the W. S. George Pottery Company and the Edwin C. McGraw Tire Company. However, factories existed that produced steel tanks, foundry work, electrical refractories, food products, electric wiring devices, wooden ventilators, fire proofing material, synthetic ice, and lumber. Around this time, East Palestine began to Begin an economy in orcharding, which still survives today. Large storage and preserving services made East Palestine the leading city for orchards in the area.