Cambridge is a city in and the county chair of Guernsey County, Ohio, United States. It lies in southeastern Ohio, in the Appalachian Plateau of the Appalachian Mountains roughly 75 miles (121 km) east of Columbus. The population was 10,089 at the 2020 census. It is the principal city of the Cambridge micropolitan Place and is located neighboring the intersection of Interstates 70 and 77.

Cambridge is with ease known accompanied by glass collectors as physical the location for the Cambridge Glass, Boyd Glass and Mosser Glass plants. The Cambridge area is also noted for its “S” shaped bridges, dating assist to the building of the National Road in 1828.

In 1796, Col. Ebenezer Zane usual funds to flare a road up to standard for travel by horse through the Ohio wilderness from a point upon the Ohio River opposite Wheeling, Virginia (now Wheeling, West Virginia) to another reduction opposite Maysville, Kentucky. Where this road, known as Zane’s Trace, crossed Wills Creek, a ferry was customary in 1798. This was followed by the first bridge authorized by the legislature of the Northwest Territory, built in 1803. The land upon which part of Cambridge stands was established to Zaccheus Biggs and Zaccheus Beatty by the giving out in 1801. A settlement grew occurring at the creek crossing. The town of Cambridge was platted there in 1806. Both Cambridge, Maryland and Cambridge, Massachusetts have been speculated by historians as having inspired the naming of the town. Also in 1806, another bureau of further on settlers from the Isle of Guernsey in the English Channel pitched camp in Cambridge, reportedly because the women in the party refused to involve on. The county for which Cambridge serves as the county chair was well ahead named in honor of its many settlers from Guernsey. In 1828, the federally built National Road came through Cambridge. The first railroad arrived in 1854. The Cambridge Place experienced terrible flooding in late June 1998.

Cambridge is located along Wills Creek; its tributary Leatherwood Creek flows into Wills Creek in the southern share of the city.