Depauville is a hamlet and census-designated place (CDP) in the southern region of the town of Clayton, within Jefferson County, New York, United States. The population was at 577 at the 2010 census.

In 1784, the Oneida people ceded everything territory to the let in of New York except for a tract of land vis-а-vis 100 square miles (260 km) known as Penet Square. The Oneida considered the tract as a gift to Pierre Penet. After Penet’s death, rights of house ownership were blurred and squatters occupied the territory as in the future as 1785. Catfish Falls was a pact at the head of the Chaumont River, named after the 25-foot (7.6 m) waterfall within the settlement. The squatters that inhabited this area were often called “Catfish People”, marking their settlement from the clearing of trees establishing its boundaries. In 1816, merchant Francis Depau purchased several lots in Penet Square including Catfish Falls, later renaming the settlement “Depauville” after himself.

Depauville during the to the fore 1800s was a site of manufacturing; the harmony contained a gristmill and sawmill. Lumber was a profitable resource for the region. Depauville with produced limewater, nearly 1,000 barrels after two years of production, a first for the county. Around 1868 the Depauville Steamboat Company was conventional and produced side-wheel steamboats. The M. W. Wright was constructed in 1968, a steam-powered vessel 70 feet (21 m) from assume stern, with a width of 14 feet (4.3 m), and weighing in at nearly 43 tons. The ship was large enough to lift concerns on its power to navigate the shallow waters of the Chaumont River past reaching Lake Ontario.

Depauville’s first Fire District was created in 1932 and during the Great Depression housed a camp of the Civilian Conservation Corps (CCC). The CCC traditional a headquarters consisting of ten camps at the Madison Barracks in Sackets Harbor.