Mesquite is an unincorporated community and census-designated place (CDP) in Doña Ana County, New Mexico, United States. The population was 1,112 at the 2010 census, up from 948 at the 2000 census. It is part of the Las Cruces Metropolitan Statistical Area.

Mesquite was traditional and named by executives of the Santa Fe Railroad after brush which grew plentifully along the tracks. The persistent desert shrub had long been a feature of the landscape. In 1847 a military coldness left El Paso, Texas, on an expedition neighboring the Apaches. Before rejection the saloon of El Paso, where “Pass Whiskey” was plentiful, they armed themselves like a supply. By the second daylight out, a part of the party where therefore befuddled that they got floating in the jungle of mesquite that grew in the area. When they finally found their way support to the main body of troops, their Commander ordered them to make camp, confiscating the perch of their whiskey, and gave them the remainder of the morning to moderate up.

Mesquite is located in southeastern Doña Ana County at 32°9′47″N 106°41′36″W / 32.16306°N 106.69333°W / 32.16306; -106.69333 (32.162976, -106.693434). It is in the Mesilla Valley, on the east side of the Rio Grande. Interstate 10 passes just east of the CDP, with entrance from Exit 151. I-10 leads northwest 13 miles (21 km) to Las Cruces, the county seat, and southeast 35 miles (56 km) to El Paso, Texas.

According to the United States Census Bureau, the Mesquite CDP has a total area of 0.81 square miles (2.1 km), all land.