Plattsmouth is a city and county chair of Cass County, Nebraska, United States. The population was 6,502 at the 2010 census.

The Lewis and Clark Expedition passed the mouth of the Platte River, just north of what is now Main Street Plattsmouth, on July 21, 1804.

Plattsmouth first appeared in 1854 as “the Barracks”, a trading post usual by Sam Martin, owner of the Platteville ferry in adjoining Mills County, Iowa, ferryman Wheatley Mickelwait, and Glenwood, Iowa attorney and politician Colonel Joseph Longworthy Sharp. The community was renamed Plattsmouth for its location at the mouth of the Platte River, and was incorporated upon March 15, 1855.

The handing out of the city under the charter of March 1855 was effected December 29, 1856, by the election of Wheatley Mickelwait to the Mayoralty, and Enos Williams, W. M. Slaughter and Jacob Vallery, Aldermen. This Council met and proceeded to business on January 29, 1857, their first ordinance, approved by the Mayor March 2, 1857, levying a tax of one-half of 1 per cent on whatever taxable property within the corporate limits of the city of Plattsmouth, the amount collected to be expended in the early payment of the streets and alleys and steamboat landings at and in the city. On December 7, 1857, the Council voted each aficionada an annual salary of $100, being something over $16 apiece for each session held during the year. This is a noticeable fact, in view of the accomplish taken by the succeeding Council on December 30, 1858, in ordaining that the Mayor and Alderman receive for their services during that year the sum of 5 cents each, payable in city scrip; the Assessor, Recorder and Treasurer creature paid $25 apiece for the same term.