Desloge ( də-LOHZH) is a city in St. Francois County, Missouri, United States. The population was 5,054 as of the 2010 census.

The city was founded by Firmin V. Desloge II, son of Firmin René Desloge, who migrated from France, settled in Potosi, and began the Desloge Family in America. Firmin V. Desloge II assistant professor about mining from his father and acquired many claims in the area of what is today Desloge and Bonne Terre. A
Desloge developed one of his claims just north of Bonne Terre and built a concentrating reforest there. After the tree-plant was destroyed by fire in 1883, Desloge explored his properties in the present area of Desloge and consolidated several local mining companies which became known as the Desloge Consolidated Lead Company. In 1887, the estate was cleared and company houses for his staff were constructed in an Place referred to as “Desloge Town”, just west of the present-day railroad tracks. Here, Desloge sank a shaft and built a concentrating reforest which began operations in 1892. Desloge Missouri and the regional Southeast Missouri Lead Mining District became one of the principal benefit mining centers in the US. In 1929, the intimates sold the Desloge Consolidated Lead Company to the St. Joe Lead Company.

Firmin Desloge II, who died in 1930, willed to his relatives the native 47 acres (190,000 m) of the hand-dug pits of the original lead mining operations and the extremely rutted wagon tracks upon a property. The family later donated this land for a park, today named Firmin Desloge Park, and dedicated it to the mining families in the area.

Firmin Desloge moved to St. Louis in the forward 1900s. His son, Firmin Desloge III, was officer of mines until he moved his family — including his sons Firmin V. Desloge IV, William Livingston Desloge, and Theodore P. Desloge — to St. Louis in 1921.